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Distinct Medial Orbitofrontal–Striatal Circuits Support Dissociable Component Processes of Risk/Reward Decision-Making

    

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Bianca Williams

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Join this interactive session as Nicole Jenni and Stan Floresco discuss their paper, “Distinct Medial Orbitofrontal–Striatal Circuits Support Dissociable Component Processes of Risk/Reward Decision-Making” with JNeurosci reviewing editor Kate Wassum. Attendees can submit questions at registration and live during the webinar.

Below is the significance statement of the paper published on March 30, 2022, in JNeurosci and authored by Nicole L. Jenni, Griffin Rutledge, and Stan B. Floresco:

The medial orbitofrontal cortex regulates a variety of goal-directed behaviors, yet the functional circuits through which it mediates higher order decision-making functions are unclear. The present study revealed that different mOFC projection pathways facilitate diverse aspects of decision-making involving risks and rewards by engaging separate networks of neurons that interface with distinct ventral and dorsal striatal targets. These findings clarify some of the normal functions of these corticostriatal pathways and may have implications for understanding how dysfunction in these circuits relate to certain psychiatric disorders.

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