DREADDING Pain: Excitatory and Inhibitory Neurons in the Periaqueductal Gray Modulate Pain

[vksamineni]

Material below summarizes the article, Divergent Modulation of Nociception by Glutamatergic and GABAergic Neuronal Subpopulations in the Periaqueductal Gray, published on March 17, 2017, in eNeuro and authored by Vijay K. Samineni, Jose G. Grajales-Reyes, Bryan A. Copits, Daniel E. O’Brien, Sarah L. Trigg, Adrian M. Gomez, Michael R. Bruchas, and Robert W. Gereau.

Pain is a conscious experience that encompasses sensory, emotional, and cognitive dimensions. Pain signals detected by nerve fibers in the skin, tissue, and peripheral organs are transmitted into the brain via the spinal cord. Once perception of pain occurs, several regions in the brain exert a powerful control of incoming pain signals in the spinal cord.

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