Evidence for Caution in the Use of Clozapine-n-Oxide for DREADD Receptor Activation

[stewartc]

Material below summarizes the article, Clozapine-n-oxide administration produces behavioral effects in Long-Evans rats - implications for designing DREADD experiments, published on October 13, 2016, in eNeuro and authored by Duncan AA MacLaren, Richard W. Browne, Jessica K. Shaw, Sandhya Krishnan Radhakrishnan, Prachi Khare, Rodrigo A España, and Stewart D. Clark.

Technologies that allow the modulation of specific neuron subtypes are powerful tools in elucidating their function and the circuitry underlying specific behaviors. There is also the promise that the understanding gained or even these technologies themselves will be used to treat human disease.

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