A Specific Population of Immature Interneurons Shapes the Dynamics of Network Activity Throughout the Developing Hippocampus

[jcwester]

Material below summarizes the article, Interneurons Differentially Contribute to Spontaneous Network Activity in the Developing Hippocampus Dependent on Their Embryonic Lineage, published on March 2, 2016, in The Journal of Neuroscience and authored by Jason C. Wester and Chris J. McBain.

A key feature of neural circuits is their ability to internally generate spontaneous bursts of network activity that can propagate as a wave over long distances. In mature brains, such activity occurs predominantly during slow-wave sleep, and there is mounting evidence that it serves to reactivate and strengthen synaptic connections formed earlier during learning and exploration.

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