Optimizing Induced Pluripotent Stem Cells to Model Schizophrenia

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Material below is adapted from the SfN Short Course, Modeling Predisposition to Schizophrenia, a Genetically Heterogeneous Neuropsychiatric Disorder, Using Induced Pluripotent Stem Cells, by Seok-Man Ho, BSc, Erin Flaherty, BSc, and Kristen J. Brennand, PhD. Short Courses are day-long scientific trainings on emerging neuroscience topics and research techniques held just prior to SfN’s annual meeting.

Schizophrenia is a chronic and severe mental disorder affecting approximately one percent of the world population. In recent years, scientists have employed animal models and genome-wide association studies to gain important insights into the biological underpinnings of schizophrenia. However, it remains unclear exactly how environmental and genetic factors interact to increase the risk for this debilitating disease.

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