GPR55: A New Mediator of Axon Guidance

[Jean_Francois_Bouchard]

Axons navigate in a complex environment with a multitude of external chemotactic cues that must be detected and effectively translated by a suitable growth response. The growth cone (GC) is the sensory structure at the axon tip that guides the axons in this landscape. Axon guidance cues help to establish functional neural circuits through guidance of axons to their specific targets during the development. At the GC surface, axon guidance molecules bind to their cognate receptors, triggering intracellular signaling cascades near the growth cone’s cell membrane and downstream signal transduction pathways that converge on the cytoskeleton and cause axon steering and growth.

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