How Misfiring of Striatal Cholingeric Interneurons Can Explain Early Cognitive Deficits in Huntington's Disease

[mlevine1]

Huntington’s disease (HD) is an inheritable neurological disorder caused by a triplet repeat (CAG) expansion in the huntingtin (HTT) gene located in the short arm of chromosome four. Symptoms include uncontrollable dance-like movements (chorea), cognitive deficits, and psychiatric disturbances. Some of the early, or prodromic, symptoms include an inability to shift attention and other behavioral inflexibilities.

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