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    REGISTER HERE! Brain disorders are highly prevalent and substantially contribute to the overall global disease burden, yet the vast majority of compounds for these disorders that have been advanced to clinical testing were later abandoned due to a lack of clinical efficacy. While there are multiple reasons for clinical failure, one of the most frequently cited is the translational validity and overall quality of the data used as the basis for clinical research. In this webinar, we will define the concept of translation, discuss how various types of preclinical research contribute to the drug development process, as well as present some of the tools that have been developed in recent years to improve the translation of innovative ideas from academic research to patient care. Finally, we will discuss a case example of where these practices have been put into place to advance scientific translation.
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    Register Here! Mala Murthy will highlight discoveries from her lab on the neural mechanisms and computations underlying social communication in the Drosophila model system and the many parallels with communication strategies in other animals, including humans. She will explain the important role of developing quantitative tools for studying behavior. She will also discuss the choices that led her and her lab down this research path and the role of effective communication in science.
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    Register Here! Over the past seven years, an in situ chemical synthesis approach to biological systems has emerged, in which functional materials are assembled within tissues such as the brain – either constructed throughout the intact tissue (hydrogel-tissue chemistry/HTC), or genetically targeted to cell types (genetically-targeted chemical assembly/GTCA). Resulting hybrid materials are endowed with diverse capabilities, including anchoring and labeling of RNA and protein, in situ sequencing, transparency, reversible size changes, and electrical insulation or conduction.
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    Register Here! Rebecca Shansky’s research investigates sexual dimorphism in fear circuitry using rodent models. Shansky’s lab integrates sophisticated behavioral analyses with high-resolution fluorescent microscopy to identify sex-specific patterns of fear expression, learning, and structural plasticity. She will discuss the challenges and surprises she’s encountered as a sex differences-focused behavioral neuroscientist, as well as her current advocacy for sex equity in animal research.
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