Below is the significance statement of the paper published on July 10, 2023 inJNeurosciand authored by Julie-Anne Balouek, Christabel A. Mclain, Adelaide R. Minerva, Rebekah L. Rashford, Shannon N. Bennett, Forrest D. Rogers and Catherine Jensen Peña.
Early-life stress enhances sensitivity to stress later in life, yet the mechanisms of such stress sensitization are largely unknown. Here, we show that neuronal ensembles in corticolimbic brain regions remain hypersensitive to stress across the lifespan, and quieting these ensembles during experience of adult stress rescues stress hypersensitivity.
Below is the significance statement of the paper published on July 10, 2023 inJNeurosciand authored by Julie-Anne Balouek, Christabel A. Mclain, Adelaide R. Minerva, Rebekah L. Rashford, Shannon N. Bennett, Forrest D. Rogers and Catherine Jensen Peña.
Early-life stress enhances sensitivity to stress later in life, yet the mechanisms of such stress sensitization are largely unknown. Here, we show that neuronal ensembles in corticolimbic brain regions remain hypersensitive to stress across the lifespan, and quieting these ensembles during experience of adult stress rescues stress hypersensitivity.