The Third International Symposium on Sigma-2 Receptors: Role in Health and Disease

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neuron
neuroscience
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Cognition Therapeutics sponsored a satellite symposium with a panel of expert speakers from the global sigma-2 community whose presentations aimed to advance our understanding of the molecular identity of the sigma-2 radioligand binding site, its protein interactions, the functional roles of the sigma-2 receptor in cellular and synaptic signaling and report clinical trial outcomes of a sigma-2 antagonist in Alzheimer’s disease patients. Speakers included Drs. Wayne Bowen of Brown University, Michael Cahill of Charles Sturt University, Timothy Kennedy of McGill University, Tara Spires-Jones of the University of Edinburgh, Stephen Martin of the University of Texas at Austin, Sonny Singh of the University of North Texas, Robert Mach and two of his colleagues, Aladdin Riad and Chenbo Zeng of the University of Pennsylvania, as well as Drs. Izzo and Catalano from Cognition Therapeutics.

This is an exceptional group of researchers and the discussion was extremely fruitful. Several abstracts were presented by these researchers at SFN2018 that disclosed major unpublished scientific information about molecular mechanisms and therapeutic clinical trial results of significance to the entire neuroscience community. To learn more, please peruse these videos.

Video archives are as follows:
Introduction to Session and Speakers
Susan Catalano, Ph.D.,
Chief Science Officer and Founder
Cognition Therapeutics, Inc.

Differential Sigma-2 Receptor/TMEM97-Mediated Cytotoxic and Metabolic Stimulative Properties of Monovalent and Bivalent SN79 Analogs
Wayne D. Bowen, Ph.D.
Upjohn Professor of Pharmacology
Professor of Biology
Chair of the Department of Molecular Pharmacology, Physiology & Biotechnology
Brown University

Targeting Sigma-2 Receptor (σ2R)/TMEM97 to Address Unmet Medical Needs in Neuroscience
Stephen F. Martin, Ph.D.
M. June and J. Virgil Waggoner Regents Chair in Chemistry
University of Texas at Austin

Sigma 2 Receptor-Interacting Protein PGRMC1 is Descended from the Hopanoid Synthetic Pathway of the Endosymbiotic Proto-Mitochondrion
Michael A. Cahill, Ph.D.
Lecturer in Biochemistry and Cell Biology
Charles Sturt University, New South Wales, Australia

Let7i as a Key Regulator of PGRMC1 and Progesterone-Induced Neuroprotection
Meharvan “Sonny” Singh, Ph.D.
Professor, Department of Pharmacology and Neuroscience
Interim Executive Director, Institute for Healthy Aging
University of North Texas Health Science Center

Clinical Evidence of Synaptic Protection in Alzheimer’s Patients following Treatment of CT1812
Susan Catalano, Ph.D.
Chief Science Officer and Founder
Cognition Therapeutics, Inc.

Sigma-2 Antagonist CT1812 Protects Synapses from Abeta Oligomer-Induced Loss, In Vitro
Nicholas J. Izzo, Ph.D.
Principal Scientist and Director of Screening
Cognition Therapeutics, Inc.

APOE4 Associated Changes in the Synaptic Proteome in Human Alzheimer’s Disease Brain
Tara Spires-Jones, DPhil
Professor of Neurodegeneration
UK Dementia Research Institute Programme Lead
Deputy Director of the Centre for Discovery Brain Sciences
University of Edinburgh, Scotland

The Essential Role of Sigma-2 Receptor/TMEM97 and Progesterone Receptor Membrane Component 1 in the Internalization of Low-Density Lipoprotein via and Interaction with the Low-Density Lipoprotein Receptor
Aladdin A. Riad, Ph.D.
Postdoctoral Fellow
University of Pennsylvania

A Novel Mechanism Underlying Synaptic Plasticity: Roles for PGRMC1 and TMEM97?
Timothy E. Kennedy, Ph.D.
co-Director, McGill Program in Neuroengineering
Professor, Department of Neurology and Neurosurgery
Professor, Department of Anatomy and Cell Biology
Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada

Biological Roles of TMEM97 and PGRMC1 in Cell Growth and Sigma-2 Ligand-Induced Cell Death
Chenbo Zeng, Ph.D.
Research Assistant Professor of Radiology
University of Pennsylvania

Identification of a Second [3H]DTG Binding Site on TMEM97-KO Cell Membranes
Robert H. Mach, Ph.D.
Britton Chance Professor of Radiology
University of Pennsylvania