This is a very tough question. I wonder whether this is applicable to all Neuroscience fields. If you read Neuroscience papers, most tell a story. Like: we found this, which was unexpected, so we did this experiment which led to this result. Based on this, we thought about doing that etc. I don’t see how you can present the research plan and methodology in a results-free manner. You somehow need to tell the reviewer which results you are going to obtain to present the next experiment. This invalidates the concept. This works if you have a “simple” question, i.e. one for which you can plan everything in advance. For example, a preclinical study to test a drug. Then, it becomes like registered reports. eNeuro is going to implement registered reports. Having said that, the results-free approach is great if it is applicable; it removes some bias.