Linking Mitochondria to Neurological Disease



Do you have any insights into the role of the DISC-1 gene in mitochondrial transport in neurons?


the size of mito varies from tissue to tissue, the diameter of a mito can be anywhere from a few hundred nm (like in synapses) to a few micros (in muscles and sperm).


there are two papers showing DISC1 affects mito motility, probably via the Miro/milton complex


does the ER has a membrane potential? some says noā€¦and what about the electromot force that generate the outer membrane potentialā€¦is intrinsic or from the inner membrane (according to Dr V Lameshko)?


Certainly it has been shown many years ago by people like Gyorgy Hajnoscky that calcium release from the ER leads to depolarization in the mitochondria. When he added a bit of IP3 to the side of a long myotube he saw a wave of calcium loss from ER that followed the loss of TMRE stain in mitos. That was about 2005 and was beautiful. So yes, certainly the oscillations can be coupled. Just not so far directly with the frequency of neurotransmitter release.


thank you, very nice you all to answer!!!


Some compounds can enter mitos passively, if they are not too hydrophilic. There are any number of transporters in mitos, some of which might bring in small molecules (e.g. pyruvate)


I think that the field pretty much agrees that there is no membrane potential across the MOM.


okā€¦currents from the inner membrane can go throug the outerā€¦and cause some potential drop or not?


Not that Iā€™m aware of


So we are losing this line now! Thank you all for listening and participating. It was a fun session and I hope we have inspired you to solve all things mitochondrial!


sure thanks more to all of you!! great!!!