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Intracranial Recordings of the Human Orbitofrontal Cortical Activity during Self-Referential Episodic and Valenced Self-Judgments

    

Sam Staples
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Register for Intracranial Recordings of the Human Orbitofrontal Cortical Activity during Self-Referential Episodic and Valenced Self-Judgments by selecting the following link.

Join this interactive session as Behzad Iravani and Josef Parvizi discuss their paper, “Intracranial Recordings of the Human Orbitofrontal Cortical Activity during Self-Referential Episodic and Valenced Self-Judgments”, with JNeurosci Reviewing Editor Erin Rich. Attendees can submit questions at registration and live during the webinar.

Below is the significance statement of the paper published March 13, 2024, in JNeurosci and authored by Behzad Iravani, Neda Kaboodvand, James R. Stieger, Eugene Y. Liang, Zoe Lusk, Peter Fransson, Gayle K. Deutsch, Ian H. Gotlib, and Josef Parvizi.

In direct recordings from the human brain, we observed significant responses characterized by high-frequency activity, aka high gamma, in distinct populations of the orbital (oPFC) and ventromedial (vmPFC) regions of the orbitofrontal cortex (OFC)—corresponding to the location of the resting-state limbic network and to a lesser extent default mode network—when human subjects were engaged in self-referential episodic memory retrieval and self-trait judgments. Notably, simultaneous recordings across the two OFC regions in the same individuals revealed earlier activations in vmPFC than oPFC, indicating that the two subregions are involved in different stages of self-referential thought processes. Lastly, in individuals with high depressive symptoms, the OFC responses were significantly reduced during positive self-judgments but not heightened during negative self-evaluations.


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