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FENS Webinar "Mechanisms of Post-ischemic Brain Adaptation"

    

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Bianca Williams

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This webinar is exclusive for SfN members. Please log in or link your FENs membership for access.

All living organisms are able to implement adaptation mechanisms that allow them to survive even in the most extreme conditions. 

Cerebral ischemia represents an extreme condition in which CNS cells are called upon to automate adaptations that ensure survival. This concept is exemplified and perfectly reproduced in the tolerance induced by the phenomena of ischemic conditioning. 

Ischemic conditioning is used to group together a few different stressors or interventions able to confer resistance to a deleterious brain event as an adaptive biological process. Ischemic conditioning through the exposure to a sub-threshold insult as above mentioned, can confer neuroprotection both if conditioning stimuli is applied before, as preconditioning stimulus, or if it is delivered after the harmful ischemia, as occurs in postconditioning. 

Over the years, several molecular pathways have been proposed as plausible mechanisms to explain the adaptive phenomena induced by hypoxia.  

This webinar will discuss mechanisms involved in post-ischemic brain adaptation . The knowledge of these mechanisms may provide information to bring light on those molecular pathways involved in brain protection. 

 In this webinar, speakers will cover points including: 

  • Post-ischemic brain remodeling and plasticity, evaluating pathomechanisms contributing to secondary brain injury and searching strategies that promote neurological recovery in the post-acute stroke phase. 

  • What the function of peripheral events in inducing brain tolerance to stroke. 

  • The plethora of factors that can influence the tolerance phenomenon occurring during pre- and post-conditioning 

  • Why it is important to escape a neuron-centric view and to consider the role of other cell types, including small vessels,  in the mechanism of brain adaptation. 

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